Aspartame may prevent, not promote, weight loss by blocking intestinal enzyme’s activity

Aspartame may prevent, not promote, weight loss by blocking intestinal enzyme's activity

A team of Massachusetts General Hospital (MGH) investigators has found a possible mechanism explaining why use of the sugar substitute aspartame might not promote weight loss. In their report published online in Applied Physiology, Nutrition and Metabolism, the researchers show how the aspartame breakdown product phenylalanine interferes with the action of an enzyme previously shown to prevent metabolic syndrome – a group of symptoms associated with type 2 diabetes and cardiovascular disease.

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